In 1960, Mrs. Lati Hyde-Forster made history as the first African Principal of Annie Walsh School. She was the first old girl to earn a Bachelor of Arts degree as well as being the first female graduate of Fourah Bay College.
| Period | Principal |
| 1849 – 1869 | Miss Sass |
| 1869 – 1870 | Mrs. Caiger |
| 1870 – 1871 | Temporary Heads |
| 1872 – 1875 | Mrs. Caiger |
| 1875 – 1878 | Miss Caspari |
| 1879 – 1883 | Mrs. Burton |
| 1883 – 1888 | Miss Ansell |
| 1888 – 1889 | Miss Anderson |
| 1889 – 1894 | Miss Dunkley |
| 1894 – 1917 | Miss Bisset |
| 1917 – 1926 | Miss Pidsley |
| 1927 – 1930 | Miss Hamblet |
| 1930 – 1954 | Miss Pole |
| 1954 – 1961 | Miss Colbeck |
| 1961 – 1975 | Mrs. Hyde – Forster |
| 1975 – 1985 | Mrs. Wilson Agwu |
| 1985 – 1995 | Mrs. G. Williams |
| 1995 – 1998 | Mrs. A.C. Roberts (Acting) |
| 1998 – 2007 | Mrs. A C. Roberts |
| 2007 – 2008 | Mrs. A. Johnson (Acting) |
| 2008 – 2022 | Mrs. O. Morrison |
| 2022 – Present | Mrs. S. Williams (Acting) |